News: An exuberant inflammatory host response to SARS-CoV-2 leads to COVID-19 - FAIS Africa

June 8, 2020 | An exuberant inflammatory host response to SARS-CoV-2 leads to COVID-19 | Immunopaedia.org.za

COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za

A recent study in Cell focused on defining the host response to SARS-CoV-2 and other human respiratory viruses in cell lines, primary cell cultures, ferrets, and COVID-19 patients. The authors show a distinct transcriptional footprint exists with SARS-CoV-2 infection when compared with other coronaviruses and common respiratory viruses such as IAV, HPIV3, and RSV. The response to SARS-CoV-2 was defined by low levels of type I and III interferons and elevated chemokines CCL2, CXCL2, CCL8, CXCL8, CXCL9, CXCL16 and high expression of IL-6. The authors propose that “reduced innate antiviral defences coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19”. Treatment modalities would therefore need to disrupt chemokine signalling along with IL-6 driven inflammation.

Journal Article: Blanco-Melo et al., 2020. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell

https://doi.org/10.1016/j.cell.2020.04.026

SOURCE: www.immunopaedia.org.za/breaking-news/an-exuberant-inflammatory-host-response-to-sars-cov-2-leads-to-covid-19

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