News: Granuloma formation during S.mansoni infection: protective or pathogenic? - FAIS Africa

November 4, 2020 | Granuloma formation during S.mansoni infection: protective or pathogenic? |

Immunology research update from

Schistosomiasis is a parasitic infection, caused by flatworms that belong to the genus Schistosoma, that affects more than 200 million globally. Schistosoma sp. has a complex life cycle which involves two hosts: snails and humans. In humans, Schistosoma sp. mature in the liver where they undergo sexual reproduction and produce eggs which are excreted in urine or faeces. As the eggs mature they secrete antigens that provoke the formation of a granuloma —an organized aggregate of macrophages and other immune cells—around it”. Granulomas often have both a protective and pathogenic role in disease. The immune system induces granuloma formation intending to restrict pathogen growth and confine infection to one site. However, some pathogens take advantage of this of the walled-off region -which is often secluded from immune cells- to replicate and grow in numbers. Uncontrolled pathogenic replication then leads to disruption of granuloma integrity resulting in spreading of the infection. A Recent study by Takaki et al. demonstrated how Schistosoma mansoni modulate granuloma formation to promote transmission.

Takaki et al., used a S.mansoni Zebrafish infection model and confocal microscopy demonstrated that only mature S.mansoni eggs induce granuloma formation, while immature eggs have limited capacity to do so. They showed that immature eggs evade granuloma formation by having an immunological inert eggshell that does not recruit macrophages. Additionally, they demonstrated that mature eggs selectively recruit macrophages (findings also demonstrated by others) but not neutrophils which results in the development of the granuloma. Lasty, they illustrated that granuloma formation is favourable for mature eggs as it enables translocation to intestinal lumen and shedding of the mature eggs.

In summary, Takaki et al., provide mechanistic evidence as to why only mature and not immature cells are shed into host faeces and demonstrated how granuloma formation in the context of S.mansoni infection is favourable to the pathogen and not the host.

Journal Article: Takaki et al., 2020. Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission. Cell Host & Microbe