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July 10, 2020 | IUIS Webinar: COVID-19 Monoclonal Abs | Immunopaedia.org.za

IUIS Webinar: COVID-19 Monoclonal Abs

COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za. In this week’s IUIS-Frontiers webinar series, Hans-Martin Jäck gave a talk on Prevention and Therapy of COVID-19 with Monoclonal Antibodies. “He introduces the concept of passive immunisation and active vaccination to prevent and protect from COVID-19, and he provides an overview of the current clinical serum and vaccine trials, finishing the webinar with a review on the production of human CoV-2 neutralising antibodies in transgenic mice with an entirely human antibody repertoire. (Source: IUIS Website)” Highlights of…

July 9, 2020 | Aging & COVID-19 | Immunopaedia.org.za

Aging & COVID-19

COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za. Chen and colleagues reviewed findings on how aging alters immunity to respiratory viral infections with the aim of suggesting potential mechanisms of age-enhanced COVID-19 mortality. They present evidence that indicated that influenza infection is associated with increased monocyte infiltration in the lung, which leads to increased levels of IL-6 and IL-β, as well as reduced T cell and B cell responses. Reduced adaptive immune responses in older individuals (> 65 years) have been attributed to the reduced capacity of antigen presentation resulting…

July 8, 2020 | Immuno-Ethiopia: Sand flies & Leishmaniasis | Immunopaedia.org.za

Immuno-Ethiopia: Sand flies & Leishmaniasis

IUIS-FAIS Immuno-Ethiopia course co-sponsored by the IUIS, FAIS and Volkswagen Foundation took place between 23rd-29th of February. The theme of this meeting was Neglected Tropical Diseases and Malaria challenges in Sub-Saharan Africa. This week we highlight talks by Dr Iva Kolarova (Charles University, Czech Republic) which focus on the Role of sand flies in Leishmania transmission and immune interactions. Dr Iva Kolarova presented a lecture on “The role of sandflies in transmission of Leishmania parasites”. She started her lecture by talking about leishmaniasis epidemiology, causative…

July 7, 2020 | Innate T cells & severe COVID-19 | Immunopaedia.org.za

Innate T cells & severe COVID-19

COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za.  COVID-19 and SARS-CoV-2 immunological research has predominantly focused on the role of innate cells such as macrophages, NK, neutrophils, and adaptive cellular and humoral immunity in pathogenesis. Recent Pre-print by Jouan and colleagues analysed the biology of innate T cells: mucosal associated invariant T (MAIT) cells, γδ T and invariant natural killer (iNK) T cells in critically ill COVID-19 patients with varying co-morbidities (46.7% with Hypertension; 30% with Type 2 diabetes; 10% with cardiovascular disease). Researchers…

July 6, 2020 | Multi-organ damage is a hallmark of severe COVID-19 | Immunopaedia.org.za

Multi-organ damage is a hallmark of severe COVID-19

COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za.  Dysregulated immune responses along with metabolic dysfunction can lead to multiple organ failure, which seems to be a hallmark of COVID-19 severity. In a recent pre-peer reviewed paper, authors used a transcriptomic, proteomic and metabolomic approach in peripheral blood to distinguish the range COVID-19 severity in 66 individuals with confirmed symptoms. There was “continuous activation of IFN-I signalling and neutrophils and a high level of inflammatory cytokines” in severe disease. COVID-19 in mild patients was “characterised…

July 3, 2020 | IUIS Webinar: COVID-19 in South Africa | Immunopaedia.org.za

IUIS Webinar: COVID-19 in South Africa

“Since the first case of COVID-19 on 5 March 2020 in South Africa, the epidemic grew exponentially with a doubling time of 2 days for the first 3 weeks until the effects of state-initiated interventions impacted reducing the doubling time to 15 days. The National response, which comprises 8 stages aims to flatten the curve. Stage 6 of the response on clinical care has provided new insights on the immune response, the role of the cytokine storm and the impact…

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